Can I take PrEP less frequently?

PrEP should be taken daily according to the first researches (IPERGAY, PROUD, and iPrex ).

However, researches showed proper protection rates even in participants that took PrEP 4 times in a week ( protection rate reached 94%).  Such a regimen is possible.However, if you forget any dose here you are in danger.

PrEP On Demand or The 2:1:1 Method

This regimen is for gay males that have frequent anal sex, Top or bottom.

in this protocol, PrEP is taken 24 hours before sex and then 2 hours before sex, this way you gain the desired protection. Afterward, PrEP is continued on 2 separate doses. “1” is 24 hours from the first dose and the other is 48 hours after the first dose.

Please note that the 2:1:1 regimen was not proved for vaginal or “front hole sex”. Furthermore, people on hormones (estradiol or testosterone) should refrain from 2:1:1 regimen and stay on the daily regimen as this regimen is the only one proved safe for them.